Interindividual Variability in Pharmacokinetics of Generic Nucleoside Reverse Transcriptase Inhibitors in TB/HIV‐Coinfected Ghanaian Patients: UGT2B7*1c Is Associated With Faster Zidovudine Clearance and Glucuronidation

Interindividual Variability in Pharmacokinetics of Generic Nucleoside Reverse Transcriptase Inhibitors in TB/HIV‐Coinfected Ghanaian Patients: UGT2B7*1c Is Associated With Faster Zidovudine Clearance and Glucuronidation

Source :

• The Journal of Clinical Pharmacology [ 0091-2700 ] ; 2009-09.

Descripteurs français

• KwdFr :
  • Adulte, Adulte d'âge moyen, Association de médicaments, Association médicamenteuse, Femelle, Foie (métabolisme), Ghana, Glucuronides (métabolisme), Glucuronosyltransferase (génétique), Humains, Infections opportunistes liées au SIDA (traitement médicamenteux), Infections à VIH (), Infections à VIH (traitement médicamenteux), Inhibiteurs de la transcriptase inverse (administration et posologie), Inhibiteurs de la transcriptase inverse (pharmacocinétique), Inhibiteurs de la transcriptase inverse (usage thérapeutique), Lamivudine (administration et posologie), Lamivudine (pharmacocinétique), Lamivudine (usage thérapeutique), Mâle, Médicaments génériques (pharmacocinétique), Médicaments génériques (usage thérapeutique), Polymorphisme génétique, Période, Stavudine (administration et posologie), Stavudine (pharmacocinétique), Stavudine (usage thérapeutique), Tuberculose (traitement médicamenteux), Tuberculose (étiologie), Zidovudine (administration et posologie), Zidovudine (pharmacocinétique), Zidovudine (usage thérapeutique).
• MESH :
  • administration et posologie : Inhibiteurs de la transcriptase inverse, Lamivudine, Stavudine, Zidovudine.
  • génétique : Glucuronosyltransferase.
  • métabolisme : Foie, Glucuronides.
  • pharmacocinétique : Inhibiteurs de la transcriptase inverse, Lamivudine, Médicaments génériques, Stavudine, Zidovudine.
  • traitement médicamenteux : Infections opportunistes liées au SIDA, Infections à VIH, Tuberculose.
  • usage thérapeutique : Inhibiteurs de la transcriptase inverse, Lamivudine, Médicaments génériques, Stavudine, Zidovudine.
  • étiologie : Tuberculose.
  • Adulte, Adulte d'âge moyen, Association de médicaments, Association médicamenteuse, Femelle, Ghana, Humains, Infections à VIH, Mâle, Polymorphisme génétique, Période.
• Wicri :
  • geographic : Ghana.

English descriptors

• KwdEn :
  • AIDS-Related Opportunistic Infections (drug therapy), Adult, Allele, Antimicrob agents chemother, Antiretroviral, Antiretroviral agents, Antiretroviral drugs, Assay, Body weight, Cell count, Chapel hill, Clearance, Clin, Clin pharmacokinet, Clin pharmacol, Clinical pharmacology, Cmax, Drug Combinations, Drug Therapy, Combination, Drug metab dispos, Drugs, Generic (pharmacokinetics), Drugs, Generic (therapeutic use), Efavirenz, Female, Generic, Generic nrtis, Genotype, Genotype frequencies, Ghana, Ghanaian, Ghanaian patients, Ghanaian patients table, Glucuronidation, Glucuronides (metabolism), Glucuronosyltransferase (genetics), HIV Infections (complications), HIV Infections (drug therapy), Half-Life, Human liver bank samples, Human liver microsomes, Humans, Immunodeficiency, Interindividual variability, Intracellular, Intracellular concentrations, Kwara, Lamivudine, Lamivudine (administration & dosage), Lamivudine (pharmacokinetics), Lamivudine (therapeutic use), Linear regression, Liver (metabolism), Liver bank samples, Liver samples, Livers zidovudine glucuronidation, Lower limit, Male, Middle Aged, Mrna, Mrna content, Noncarrier, Noncarrier carrier, Noncarriers, Nrti, Patients cmax, Peak concentration, Pharmacokinetic, Pharmacokinetic parameters, Pharmacokinetic testing, Pharmacokinetics, Pharmacol, Polymorphism, Polymorphism, Genetic, Possible effects, Protein content, Reverse Transcriptase Inhibitors (administration & dosage), Reverse Transcriptase Inhibitors (pharmacokinetics), Reverse Transcriptase Inhibitors (therapeutic use), Rifampin, Significant differences, Snp, Stavudine, Stavudine (administration & dosage), Stavudine (pharmacokinetics), Stavudine (therapeutic use), Tmax, Toxicity, Transcriptase inhibitors, Transporter, Tuberculosis (drug therapy), Tuberculosis (etiology), Zidovudine, Zidovudine (administration & dosage), Zidovudine (pharmacokinetics), Zidovudine (therapeutic use), Zidovudine clearance, Zidovudine glucuronidation, Zidovudine glucuronidation activity, Zidovudine metabolism, Zidovudine pharmacokinetic parameters, Zidovudine pharmacokinetics.
• MESH :
  • chemical , administration & dosage : Lamivudine, Reverse Transcriptase Inhibitors, Stavudine, Zidovudine.
  • chemical , genetics : Glucuronosyltransferase.
  • chemical , metabolism : Glucuronides.
  • chemical , pharmacokinetics : Drugs, Generic, Lamivudine, Reverse Transcriptase Inhibitors, Stavudine, Zidovudine.
  • chemical , therapeutic use : Drugs, Generic, Lamivudine, Reverse Transcriptase Inhibitors, Stavudine, Zidovudine.
  • geographic : Ghana.
  • complications : HIV Infections.
  • drug therapy : AIDS-Related Opportunistic Infections, HIV Infections, Tuberculosis.
  • etiology : Tuberculosis.
  • metabolism : Liver.
• Teeft :
  • Adult, Allele, Antimicrob agents chemother, Antiretroviral, Antiretroviral agents, Antiretroviral drugs, Assay, Body weight, Cell count, Chapel hill, Clearance, Clin, Clin pharmacokinet, Clin pharmacol, Clinical pharmacology, Cmax, Drug Combinations, Drug Therapy, Combination, Drug metab dispos, Efavirenz, Female, Generic, Generic nrtis, Genotype, Genotype frequencies, Ghanaian, Ghanaian patients, Ghanaian patients table, Glucuronidation, Half-Life, Human liver bank samples, Human liver microsomes, Humans, Immunodeficiency, Interindividual variability, Intracellular, Intracellular concentrations, Kwara, Lamivudine, Linear regression, Liver bank samples, Liver samples, Livers zidovudine glucuronidation, Lower limit, Male, Middle Aged, Mrna, Mrna content, Noncarrier, Noncarrier carrier, Noncarriers, Nrti, Patients cmax, Peak concentration, Pharmacokinetic, Pharmacokinetic parameters, Pharmacokinetic testing, Pharmacokinetics, Pharmacol, Polymorphism, Polymorphism, Genetic, Possible effects, Protein content, Rifampin, Significant differences, Snp, Stavudine, Tmax, Toxicity, Transcriptase inhibitors, Transporter, Zidovudine, Zidovudine clearance, Zidovudine glucuronidation, Zidovudine glucuronidation activity, Zidovudine metabolism, Zidovudine pharmacokinetic parameters, Zidovudine pharmacokinetics.

Abstract

• https://api.istex.fr/document/15A62A64732DE5905CD3D180C41C9182403ED5E1/fulltext/pdf
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749505

Affiliations:

• Ghana, États-Unis
• Caroline du Nord, Massachusetts, Rhode Island, Région du Grand Accra
• Accra

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